|
T9029 |
STING-IN-3
|
C-171 |
STING
|
|
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. |
|
T13015 |
STING agonist-4
|
|
STING
|
|
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM). |
|
T7329 |
C-178
|
|
STING
|
|
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. |
|
T13613 |
ChX710
|
|
STING
|
|
ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory ... |
|
T9554 |
SN-008
|
|
STING
|
|
SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control. |
|
T8798 |
MSA-2
|
|
STING
|
|
MSA-2 is a potent and orally available non-nucleotide STING agonist. |
|
T5674 |
H-151
|
|
STING
|
|
H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammator... |
|
T9853 |
STING activator Compound 53
|
|
STING
|
|
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons... |
|
T6919 |
Omaveloxolone
|
RTA-408 |
Apoptosis
,
Others
,
Nrf2
,
STING
|
|
Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2. |
|
T8655 |
SR-717
|
|
STING
|
|
SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens. |
|
T5154 |
C-176
|
C176,STING inhibitor 1 |
STING
|
|
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor |
|
T5516 |
DiABZI STING agonist-1 trihydrochloride
|
|
STING
|
|
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. |
|
T8328 |
STING agonist-1
|
G10 |
Virus Protease
,
STING
|
|
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses. |
|
T9028 |
STING-IN-2
|
C-170 |
STING
|
|
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research. |
|
T83775 |
STING Agonist 12L
|
Stimulator of Interferon Genes Agonist 12L |
|
|
STING agonist 12L is a stimulator of interferon genes (STING) agonist that exhibits binding affinity for both wild-type STING and its variants R232, AQ, and Q with half-maximal inhibitory concentrations (IC50s) of 1.15 µ... |
|
T7081 |
CCCP
|
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone |
Apoptosis
,
IκB/IKK
,
COX
,
Mitochondrial Metabolism
,
STING
,
IFNAR
,
Antibacterial
|
|
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ... |
|
T83841 |
STING Agonist D61
|
D61,Stimulator of Interferon Genes Agonist D61 |
|
|
STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular as... |
|
T6273 |
Vadimezan
|
DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 |
Influenza Virus
,
VDA
,
STING
,
IFNAR
|
|
Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without aff... |
|
T10252L2 |
ADU-S100 ammonium salt
|
ML RR-S2 CDA ammonium salt,MIW815 ammonium salt |
STING
|
|
|
|
T9137 |
SN-011
|
[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901 |
STING
|
|
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845. |
|
T11035 |
DiABZI STING agonist-1 (Tautomerism)
|
diABZI STING agonist (Compound 3) |
STING
|
|
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
|
T72482 |
Dazostinag disodium
|
|
STING
|
|
Dazostinag disodium (TAK-676) is a novel stimulator of interferon genes (STING) agonist and immune system modulator with antitumor activity that activates dendritic cells, natural killer cells, and T cells. |
|
T10834 |
CL656
|
c-[2’FdAMP(S)-2’FdIMP(S)] |
Others
|
|
CL656 is a stimulator of interferon genes (STING) activator. |
|
T10252L3 |
ADU-S100
|
ML RR-S2 CDA,MIW815 |
Others
|
|
ADU-S100 is an activator of stimulator of interferon genes (STING). |
|
T10252 |
ADU-S100 disodium salt
|
ML RR-S2 CDA disodium salt,MIW815 disodium salt |
Others
|
|
|
|
T10252L |
ADU-S100 enantiomer ammonium salt
|
MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt |
Others
|
|
ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). |
|
T81082 |
STING-IN-7
|
|
STING
|
|
STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of 11.5 nM. It effectively hampers the phosphorylation of both... |
|
T38162 |
STING18
|
|
|
|
STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β productio... |
|
T38159 |
STING Agonist 12b
|
|
|
|
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 ... |
|
T82043 |
Iso5-2DC18
|
|
|
|
Iso5-2DC18, a lipid, is utilized in the synthesis of amine-containing lipids, which are instrumental in mRNA delivery, activation of the stimulator of interferon genes (STING) pathway, and demonstration of anti-tumor imm... |
|
T75086 |
Dazostinag
|
|
|
|
Dazostinag (TAK-676 free base) functions as a stimulator of interferon genes (STING) protein agonist, exhibiting antineoplastic properties. It also acts as a payload for the synthesis of antibody-drug conjugates (ADCs) [... |
|
T73746 |
DiABZI STING agonist-1
|
|
|
|
DiABZI STING Agonist-1 is a selective receptor agonist for the stimulator of interferon genes (STING), demonstrating efficacy with EC50 values of 130 nM and 186 nM in human and mouse models, respectively. |
|
T38122 |
5'-pGpG (sodium salt)
|
|
|
|
5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahy... |
|
T74676 |
STING agonist-20-Ala-amide-PEG2-C2-NH2
|
|
|
|
STING agonist-20-Ala-amide-PEG2-C2-NH2, an active scaffolding molecule, engages the stimulator of interferon genes (STING) pathway and can be employed in the synthesis of immune-stimulating antibody conjugates (ISAC). Th... |
|
T79320 |
Antitumor agent-114
|
|
STING
|
|
Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models, demonstrating potential applications in immunity and cance... |
|
T74268 |
STING agonist-13
|
|
|
|
STING Agonist-13, a stimulator of interferon genes (STING) agonist, enhances cancer immunity through STING-mediated immune activation. It activates STING downstream signaling to promote type I interferon immune responses... |
|
T38091 |
3'3'-cGAMP (sodium salt)
|
|
|
|
3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. It contains canonical 3'5'-phosphodiester bonds and regulates chemotaxis, colonization, and other cellular functions. 3'3'-cGAMP sh... |
|
T74726 |
CL845
|
|
|
|
CL845, a STING (stimulator of interferon genes) agonist analog to CL656, is instrumental in synthesizing conjugatable PRR (pattern recognition receptor) ligands aimed at targeting STING. It holds potential applications i... |
|
T74677 |
STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
|
|
|
|
STING Agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA, an active compound that interacts with the stimulator of interferon genes (STING), is utilized in the synthesis of immune-stimulating antibody conjugates (ISAC).... |
|
T35654 |
2'2'-cGAMP (sodium salt)
|
|
|
|
2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that... |
|
T75011 |
STING-IN-5
|
|
STING
|
|
STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. T... |
|
T35422 |
5'-pApA (sodium salt)
|
|
|
|
5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedvia... |
|
T38160 |
STING Agonist 1a
|
|
|
|
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expres... |
|
T79313 |
BI 7446
|
|
STING
|
|
BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor ... |
|
T72516 |
IACS-8779 disodium
|
|
|
|
IACS-8779 disodium, a highly potent STING (stimulator of interferon genes) agonist, demonstrates robust activation of the STING pathway in vitro, along with superior systemic antitumor efficacy. This compound shows a sig... |
|
T36461 |
CAY10748
|
CAY10748 |
|
|
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, re... |
|
T74693 |
CDN-A
|
|
|
|
CDN-A, a cyclic di-nucleotide, serves as a precursor for synthesizing antibody-drug conjugates (ADC) and acts as a potent stimulator of both innate and adaptive immune responses. In humans, these cyclic di-nucleotides, p... |
|
T83901 |
BDW568
|
|
|
|
BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value ... |
|
T38161 |
STING Agonist C11
|
STING Agonist C11 |
|
|
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory... |
|
T83874 |
S-72
|
|
|
|
S-72 acts as a microtubule polymerization inhibitor, effective in cell-free assays at concentrations of 1, 3, and 10 µM. At nanomolar levels (IC50s = 15.64 and 26.32 nM, respectively), it diminishes the viability of both... |
